216-287-0821 |
emilfriedman@gmail.com
|
BS from M.I.T, PhD from
Experienced statistician - strong background in chemistry, polymer
science & engineering.
Consulting projects have covered wide variety of (often unique) situations.
Internal statistical consultant for R&D and manufacturing
plants. Led collaborative teams to:
define questions and design
experiments to answer them,
improve processes & products,
diagnose & solve wide range of technical & quality problems,
remove unnecessary constraints and work around necessary ones.
Devised curriculum & successfully taught applied statistics in
industry and online.
Extensive experience with JMP, SAS, and graphical display of data.
Extensive experience with wide variety of statistical methods.
EXPERIENCE:
·
Calculated odds of winning various
promotional games. Devised new games.
·
Designed & analyzed experiments
to test new method of removing secretions from endotracheal tubes.
·
Designed & analyzed trials to
prevent infection by Israel Acute Paralysis Virus.
·
Interpreted statistical aspects of
DNA data for counsel in criminal trial.
·
Identified unexpected spatial
component in agricultural data.
http://statisticalconsulting.org/Shafir.pdf
·
Designed and analyzed experiments
related to smoke density & heat release (Schneller, Inc).
·
Statistically modeled market prices
for Booz-Allen-Hamilton.
·
Cluster and related analyses for
marketing firm.
·
Distributional analysis for jitter in
oscilloscopes.
·
Modeled tire aging for Akron Rubber
Development Lab (analogous to Rx stability below).
·
Performed
statistical analyses & consulted on study designs that supported regulatory
submissions, ensured defensibility to external scrutiny, manufacturing, analytics,
etc
·
Rapid
Microbial Tests with Substantially Improved Statistical Properties (see
publications)
·
Devised
methods to extrapolate shelf life under multiple storage conditions (see publications)
·
Design
& analysis of experiments. Taught
courses in same.
·
“Extremely
complex problems of diverse scope…”
·
Representative
to IPAC-RS Delivered Dose Uniformity (DDU) Working Group
·
Investigated alternatives to ICH Guidance Q1E when stability data
available from ≥10 lots.
·
Calculate release and shelf life
limits for quality department
·
Design of experiments & multiple
criteria optimization for chemical processes.
·
Mathematically modeled continuous
process wherein API was in the tablet coating.
·
Devised ad hoc sampling plan for unusual situation faced by other
statisticians.
·
Modeled pharmaceutical stability, set
tolerance intervals, recommended methodologies, etc.
·
Validated complex SAS program for
Peto-Pike carcinogenicity studies.
SAS Institute, Contract Instructor
(Statistics Using JMP Software) 2003
- 2005
“Goodyear Spirit Award”,
1989.
Quotes from performance appraisals: “…recognized and much-sought internal consultant and expert in statistical methods and their application to real problem solving….Excellent listener and dissector of the key needs/wishes of his customers….Focuses their work to answer their desired questions, and creates experimental approaches specific to each problem.” “Emil has internalized the principals of Total Quality Culture”.
·
Chaired curriculum committee. Developed, wrote and taught many portions of
internal statistics courses, including workshop in Multiple Criteria
Optimization. Associates consistently said that I made previously difficult
concepts easy to understand.
·
Reduced measurement variation in
production process by a factor of 10.
·
Identified root cause of expensive
adhesion difficulties.
·
Prevented expensive (>$500,000/yr)
& unnecessary change in bladder compound.
·
Invented and developed emulsion
polymers & polymer processes to satisfy product needs.
·
Extensive use of
a wide variety of statistical
methods (eg, designed experiments, linear & non-linear regression,
assessing measurement systems, sources of variation, Multiple Criteria
Optimization, happenstance data, mixed models, ANOVA, ANOCOVA).
·
Identified root causes of major polymer deficiencies and
devised improvements.
·
Synthesized polymers to meet specific needs.
·
Software development as needed.
Polymer Science Dept, Univ of Mass (Roger S Porter), Post-doctoral research position, 1973 - 74
Regional Chair, MIT Educational Council ?
- 2005
Math tutor - supposedly “lost” students achieved A’s in 11th grade math. 2004
4,254013 4,574,140 4,960,819 5,162,425
PRESENTATIONS:
Invited speaker, ASM International (Akron
Chapter), Akron Rubber Group Lecture
Series (twice), national meeting
of American Chemical Society. Many
internal seminars.
PUBLICATIONS:
“Non-Transitivity, Correlation and Causation”, Emil M Friedman. (2015) The
American Statistician, 69:3, 257, http://www.tandfonline.com/eprint/wnpZDGAnFJh3cEuGZcen/full
“In-Process
Microbial Testing: Statistical
Properties of a Rapid Alternative to Compendial Enumeration Methods”, Emil M.
Friedman, Mark Warner, Sam C. Shum, Fred Adair.
PDA Journal of Pharmaceutical
Science and Technology, Vol 69, 264-269 (2015) http://statisticalconsulting.org/PDAJournal2015Friedman264-9.pdf
"Challenges and Opportunities in Implementing the
FDA Default Parametric Tolerance Interval Two-One Sided Test for Delivered Dose
Uniformity of Orally Inhaled Products", Greg Larner, Andrew Cooper,
Svetlana Lyapustina, Stefan Leiner, David Christopher, Helen Strickland,
Michael Golden, Hans-Joachim Delzeit, Emil M. Friedman. AAPS
PharmaSciTech. Vol 12, 1144-56 (2011) http://www.ncbi.nlm.nih.gov/pubmed/21901649.
“Stability
Models for Sequential Storage”, Emil M Friedman and Sam C Shum. AAPS
PharmaSciTech , vol 12, pp 96-103 (2011).
DOI 10.1208/s12249-010-9558-x. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066345/) Poster by Emil M Friedman at 33rd Annual Midwest Biopharmaceutical
Statistics Workshop,
“Inspiratory Efforts Achieved in Use of the
Technosphere® Insulin Inhalation System”,
“NIR Chemical Imaging to Guide/Support BMS-561389
Tablet Formulation Development”, L. Hilden, C.J. Pommiera,
“Modality of Molecular Weight Distributions”, Emil M
Friedman, Polymer Engineering and
Science, 30, 569 (1990). http://dx.doi.org/10.1002/pen.760301002
“High Conversion Emulsion Polymerization in a
Continuous Reactor: Predictions Using
Smith-Ewart Kinetics”, Emil M Friedman, J
Polymer Sci, Polym Phys Ed, 18, 1771 (1980). http://dx.doi.org/10.1002/pol.1980.180180809
“Elastomer Blends – Improved Strength…of Uncured
Rubber Compounds”, Emil M Friedman, Richard G Bauer, and Diego C Rubio, in Polymer Alloys, ed D Klempner and K C
Frisch (Plenum, NY, 1977), p 51. Also
presented at National ACS Meeting.
“Nematic-Like Flow Behavior in a Non-Steroidal
Cholesteric Mesophase”, Emil M Friedman and Roger S Porter, Molecular
“Polymer Viscosity-Molecular Weight Distribution
Correlations via Blending…”, Emil M Friedman and Roger S Porter, Transactions of the Society of Rheology, 49,
493, (1975). http://dx.doi.org/10.1122/1.549382
“Effect of a
Cholesteric Texture on X-ray Diffraction…Liquid Crystalline Polypeptides”, Emil
M Friedman and Ryong-Joon Roe, Molecular
“
EDUCATION:
Massachusetts Institute of
Technology, Chemical Physics, BS. 1968